kaberett | [migraine] stabs (Reply)

Next batch of stabs was actually due tomorrow, but I decided that Sod This and have instead stabbed myself today. I... am sat on the sofa with all the living room lights on, and no sunglasses, and the ability to use appropriate nouns and indeed whole sentences verbally.

Which is an improvement over yesterday! And I'm suspicious about it actually kicking in that quickly, notwithstanding having taken myself off for a nap after having my important post-stabs trifle, but if it's placebo effect I'll Take It, Thanks.

Which means that I am probably going to wait until Monday and then if I'm still doing alright cancel the Rescue Stabs in-person appointment we made for the 25^th.

Re placebo effect, time to onset, etc: I went and hunted some info about all of this the other week when I was looking up pharmacokinetics (with the aim of working out whether the weird gel-like extrusion from last month's injection site might have contained a significant quantity of drug). Of particular note for my purposes, and no this is not exhaustive it was just a very quick skim: Detke et al. 2019 ("Daily analysis showed onset of effect at Day 1 (first day after injection day") and Kielbasa and Helton (2019) ("... antibody absorption following IM or SC administration can occur for days, resulting in maximum antibody concentrations in serum ∼1 to 2 weeks post administration. For galcanezumab, the time to maximum concentration is 5 days...").

The former suggests there's a reasonable chance it's not placebo; the latter is interesting-to-me context on some of why it might have taken approximately two weeks for the effects to kick in for me.